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dc.contributor.authorKermanizadeh, Ali
dc.contributor.authorJacobsen, Nicklas R
dc.contributor.authorMroczko, Agnieszka
dc.contributor.authorBrown, David
dc.contributor.authorStone, Vicki
dc.date.accessioned2022-03-07T12:33:06Z
dc.date.available2022-03-07T12:33:06Z
dc.date.issued2022-01-11
dc.identifier.citationKermanizadeh, A., Jacobsen, N.R., Mroczko, A., Brown, D. and Stone, V. (2022). 'Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures'. Nanotoxicology, pp. 1-17.en_US
dc.identifier.pmid35015612
dc.identifier.doi10.1080/17435390.2021.2020350
dc.identifier.urihttp://hdl.handle.net/10545/626345
dc.description.abstractWith ever-increasing production and use of nanoparticles (NPs), there is a necessity to evaluate the probability of consequential adverse effects in individuals exposed to these particles. It is now understood that a proportion of NPs can translocate from primary sites of exposure to a range of secondary organs, with the liver, kidneys and spleen being some of the most important. In this study, we carried out a comprehensive toxicological profiling (inflammation, changes in serum biochemistry, oxidative stress, acute phase response and histopathology) of Ag NP induced adverse effects in the three organs of interest following acute exposure of the materials at identical doses via intravenous (IV), intratracheal (IT) instillation and oral administration. The data clearly demonstrated that bioaccumulation and toxicity of the particles were most significant following the IV route of exposure, followed by IT. However, oral exposure to the NPs did not result in any changes that could be interpreted as toxicity in any of the organs of interest within the confines of this investigation. The finding of this study clearly indicates the importance of the route of exposure in secondary organ hazard assessment for NPs. Finally, we identify Connexin 32 (Cx32) as a novel biomarker of NP-mediated hepatic damage which is quantifiable both (in vitro) and in vivo following exposure of physiologically relevant doses.en_US
dc.description.sponsorshipThis work has been financially supported by SULSA and H2020 funded project PATROLS [Grant code – 760813]. NRJ received funding from FFIKA, Focused Research Effort on Chemicals in the Working Environment, from the Danish Government.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.urlhttps://www.tandfonline.com/doi/full/10.1080/17435390.2021.2020350en_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectAg NPsen_US
dc.subjectConnexin 32en_US
dc.subjectLiveren_US
dc.subjectacute-phase responseen_US
dc.subjectdifferent routes of exposureen_US
dc.subjectinflammationen_US
dc.subjectkidneysen_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectspleenen_US
dc.titleAcute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.en_US
dc.typeArticleen_US
dc.identifier.eissn1743-5404
dc.contributor.departmentUniversity of Derbyen_US
dc.contributor.departmentNational Research Centre for the Working Environment, Copenhagen, Denmarken_US
dc.contributor.departmentHeriot Watt University, Edinburghen_US
dc.identifier.journalNanotoxicologyen_US
dc.source.journaltitleNanotoxicology
dc.source.beginpage1
dc.source.endpage17
dcterms.dateAccepted2021-12-15
refterms.dateFOA2022-03-07T12:33:07Z
dc.author.detail301374en_US
dc.source.countryEngland


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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal