Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures.
AffiliationUniversity of Derby
National Research Centre for the Working Environment, Copenhagen, Denmark
Heriot Watt University, Edinburgh
MetadataShow full item record
AbstractWith ever-increasing production and use of nanoparticles (NPs), there is a necessity to evaluate the probability of consequential adverse effects in individuals exposed to these particles. It is now understood that a proportion of NPs can translocate from primary sites of exposure to a range of secondary organs, with the liver, kidneys and spleen being some of the most important. In this study, we carried out a comprehensive toxicological profiling (inflammation, changes in serum biochemistry, oxidative stress, acute phase response and histopathology) of Ag NP induced adverse effects in the three organs of interest following acute exposure of the materials at identical doses via intravenous (IV), intratracheal (IT) instillation and oral administration. The data clearly demonstrated that bioaccumulation and toxicity of the particles were most significant following the IV route of exposure, followed by IT. However, oral exposure to the NPs did not result in any changes that could be interpreted as toxicity in any of the organs of interest within the confines of this investigation. The finding of this study clearly indicates the importance of the route of exposure in secondary organ hazard assessment for NPs. Finally, we identify Connexin 32 (Cx32) as a novel biomarker of NP-mediated hepatic damage which is quantifiable both (in vitro) and in vivo following exposure of physiologically relevant doses.
CitationKermanizadeh, A., Jacobsen, N.R., Mroczko, A., Brown, D. and Stone, V. (2022). 'Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures'. Nanotoxicology, pp. 1-17.
PublisherTaylor & Francis
The following license files are associated with this item:
- Creative Commons
- Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice.
- Authors: Modrzynska J, Berthing T, Ravn-Haren G, Jacobsen NR, Weydahl IK, Loeschner K, Mortensen A, Saber AT, Vogel U
- Issue date: 2018 Jan 3
- Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure.
- Authors: Kreyling WG, Holzwarth U, Hirn S, Schleh C, Wenk A, Schäffler M, Haberl N, Gibson N
- Issue date: 2020 Jun 5
- Eco-Friendly Synthesis of Silver Nanoparticles Through Economical Methods and Assessment of Toxicity Through Oxidative Stress Analysis in the Labeo Rohita.
- Authors: Khan MS, Qureshi NA, Jabeen F, Asghar MS, Shakeel M, Fakhar-E-Alam M
- Issue date: 2017 Apr
- Oxidative stress following exposure to silver and gold nanoparticles in mice.
- Authors: Shrivastava R, Kushwaha P, Bhutia YC, Flora S
- Issue date: 2016 Aug
- Low hazard of silver nanoparticles and silver nitrate to the haematopoietic system of rainbow trout.
- Authors: Clark NJ, Shaw BJ, Handy RD
- Issue date: 2018 May 15