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dc.contributor.authorCarvalho, Serafim
dc.contributor.authorCaetano, Filipa
dc.contributor.authorPinto-Gouveia, José
dc.contributor.authorMota-Pereira, Jorge
dc.contributor.authorMaia, Dulce
dc.contributor.authorPimentel, Paulo
dc.contributor.authorPriscila, Cátia
dc.contributor.authorGilbert, Paul
dc.date.accessioned2021-09-07T11:30:29Z
dc.date.available2021-09-07T11:30:29Z
dc.date.issued2020-07-10
dc.identifier.citationCarvalho, S., Caetano, F., Pinto-Gouveia, J., Mota-Pereira, J., Maia, D., Pimentel, P., Priscila, C. and Gilbert, P., (2020). 'Predictors of poor 6-week outcome in a cohort of major depressive disorder patients treated with antidepressant medication: the role of entrapment'. Nordic journal of psychiatry, pp. 1-11.en_US
dc.identifier.issn0803-9488
dc.identifier.doi10.1080/08039488.2020.1790657
dc.identifier.urihttp://hdl.handle.net/10545/625986
dc.description.abstractOnly a small number of consistent processes predict which depressed patients will achieve remission with antidepressant medication. One set of processes is that of social ranking strategies/variables that are related to life events and severe difficulties. Particularly, defeat and entrapment predict poorer response to antidepressants. However, results are inconsistent. The current study aimed to evaluate evolutionary strategies, childhood maltreatment, neglect and life events and difficulties (LEDs) as predictors of remission in depressed patients undergoing pharmacological treatment in a psychiatric outpatient sample. A cohort of 139 depressed outpatients undergoing pharmacological treatment was followed prospectively in a naturalistic study for 6 weeks. Two major evaluations were considered at baseline and 6 weeks. We allocated patients to a pharmacological treatment algorithm for depression – the Texas Medication Algorithm Project. Variables evaluated at baseline and tested as predictors of remission included demographic and clinical data, severity of depression, social ranking, evolution informed variables, LEDs and childhood maltreatment. Of the 139 patients, only 24.5% were remitted at week 6. In univariate analyses, non-remitted patients scored significantly higher in all psychopathology and vulnerability scales except for submissive behaviour and internal entrapment. For the logistic regression, a higher load of LEDs of the entrapment and humiliation dimension in the year before the index episode (OR = 6.62), and higher levels external entrapment in the Entrapment Scale (OR = 1.10) predicted non-remission. These variables accounted for 28.7% of the variance. Multivariate analysis revealed that external entrapment was the only predictor of non-remission.en_US
dc.description.sponsorshipN/Aen_US
dc.language.isoenen_US
dc.publisherInforma UK Limiteden_US
dc.relation.urlhttps://www.tandfonline.com/doi/abs/10.1080/08039488.2020.1790657en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPsychiatry and Mental healthen_US
dc.subjectmajor depressive disorderen_US
dc.subjectpharmacological treatmenten_US
dc.subjectchildhood maltreatmenten_US
dc.subjectlife eventsen_US
dc.subjectentrapmenten_US
dc.subjectsocial rankingen_US
dc.titlePredictors of poor 6-week outcome in a cohort of major depressive disorder patients treated with antidepressant medication: the role of entrapmenten_US
dc.typeArticleen_US
dc.identifier.eissn1502-4725
dc.contributor.departmentHospital de Magalhães Lemos, Porto, Portugalen_US
dc.contributor.departmentUniversidade de Coimbra, Portugalen_US
dc.contributor.departmentClínica Médico-Psiquiátrica da Ordem, Porto, Portugalen_US
dc.contributor.departmentDepartamento de Psiquiatria e Saúde Mental, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugalen_US
dc.contributor.departmentUniversity of Derbyen_US
dc.identifier.journalNordic Journal of Psychiatryen_US
dc.identifier.pii10.1080/08039488.2020.1790657
dc.source.journaltitleNordic Journal of Psychiatry
dc.source.beginpage1
dc.source.endpage11
dcterms.dateAccepted2020-06-29
dc.author.detailVCHI583en_US


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International